Xiaochuang Shu1,2,3, Guozhi Wu1,2,3, Yanjun Zhang4, Yuping Wang2,3, Ya Zheng2,3, Qinghong Guo2,3, Rui Ji2,3, Yongning Zhou2,3
Ann Transl Med. 2021 Mar;9(6):506. doi: 10.21037/atm-21-1051.
Background: The diagnostic value of linked color imaging based on endoscopy for gastric intestinal metaplasia has shown variable results. Therefore, this meta-analysis sought to systematically evaluate the value of linked color imaging (LCI) based on the blue laser endoscopy system for the diagnosis of gastric intestinal metaplasia (GIM).
Methods: Literature searches were conducted of electronic databases including PubMed, Embase, the Cochrane Library, and Web of Science to screen diagnostic tests of LCI. The random-effects model was adopted to calculate the diagnostic efficacy of LCI for GIM. Meta-DiSc 1.40 software was applied for the calculation of sensitivity, specificity, and likelihood ratios; symmetric receiver operator characteristic (SROC) curves were drawn, and the areas under the SROC curves (AUCs) were computed. Quality of the included studies was chosen to assess using the quality assessment of diagnostic accuracy studies-2 (QUADAS-2) tool.
Results: Six original studies involving 700 participants were included in the meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of LCI for diagnosing GIM were 0.87 (0.83-0.91), 0.86 (0.82-0.89), 5.72 (3.63-8.99), and 0.17 (0.08-0.36), respectively. SROC curve analysis showed that the AUC value was 0.9283.
Discussion: Our study shows that LCI can be used for the accurate diagnosis of GIM. Considering weaknesses of available studies in terms of design, further studies with rigorous design are in need for further validating the findings of this meta-analysis.
1 The First Clinical Medical College of Lanzhou University, Lanzhou, China
2 Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China
3 Key Laboratory for Gastrointestinal Diseases of Gansu Province, Lanzhou University, Lanzhou, China
4 General Internal Medicine Department of Donggang Branch, The First Hospital of Lanzhou University, Lanzhou, China