Min M1, Deng P1 etc
Gastrointest Endosc. 2017 Mar 9. Impact factor 5.369
Background and Aims: Linked color imaging (LCI) is a recently developed technology that uses a laser endoscopic system to enhance the color separation of red color to depict red and white colors more vividly. The benefits of LCI in colorectal polyp detection remain unknown. The aim of this study was to assess the ability of LCI to increase colorectal polyp detection compared to white-light (WL) endoscopy.
Methods: We performed a multicenter, crossover, prospective, randomized controlled trial in three hospitals in China. All patients underwent crossover colonoscopies with LCI and WL endoscopy in a randomized order. All lesions were removed during the second endoscopic procedure. The primary outcome measure was the difference in sensitivity between LCI and WL endoscopy for the detection of colorectal polyps. The secondary outcome measures were the adenoma detection rate per patient in the two groups and the factors associated with polyp miss rates.
Results: A total of152 patients were randomized, and 141 were included in the analysis. The overall polyp detection rate increased significantly by 24% for LCI colonoscopy, corresponding to a higher sensitivity of LCI than WL endoscopy (91% vs 73%, P<0.0001). Furthermore, LCI identified significantly more patients (32%) with polyps. The per-patient adenoma detection rate was significantly higher for LCI than WL endoscopy (37% vs 28%, 95% CI, 2.39% – 19.41%).
Conclusion: LCI improves the detection of colorectal polyps and adenomas during colonoscopy.